The Beneficial Role of the Thyroid Hormone Receptor Beta 2 (<i>thrb2</i>) in Facilitating the First Feeding and Subsequent Growth in Medaka as Fish Larval Model.

ABSTRACT: During the early growth stages of fish larvae, there are significant challenges to their viability, so improving their visual environment is essential to promoting their growth and survival. Following the successful knockout of thyroid hormone receptor beta 2 (thrb2) using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology, there was an increase in the expression of UV opsin (short-wave-sensitive 1, sws1), while the expression of other cone opsins was significantly decreased. Further analysis of the retinal structure demonstrated that the thrb2 knockout resulted in an increased lens thickness and a decreased thickness of the ganglion cell layer (GCL), outer plexiform layer (OPL), and outer nuclear layer (ONL) in the retina. The slowing d

SUBMITTER: Wu J 

PROVIDER: S-EPMC11898640 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature