The Na⁺-K⁺-ATPase alpha subunit is an entry receptor for white spot syndrome virus.

ABSTRACT: White spot syndrome virus (WSSV) is a debilitating viral pathogen that poses a significant threat to the global crustacean farming industry. It has a wide host tropism because it uses several receptors to facilitate its attachment and entry. Thus far, not all the receptors have been identified. Here, we employed a BioID-based screening method to identify the Na⁺-K⁺-ATPase alpha subunit (PvATP1A) as a potential receptor in Penaeus vannamei. Although during the early stages of WSSV infection, PvATP1A was induced and underwent oligomerization, clustering, and internalization, knockdown of PvATP1A inhibited viral entry and replication. PvATP1A interacted with the WSSV envelope protein VP28 through its multiple extracellular regions, wher

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11898654 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature