Detection of Bioactive Peptides' Signature in Podolica Cow's Milk.

ABSTRACT: The aim of this study was to identify and characterize the bioactive peptide profile of Podolica cow's milk. This dairy product is known for its nutritional properties related to the presence of peculiar lipids and is a typical breed traditionally reared in southern Italy. Using top-down peptidomics, we identified 2213 peptides in milk samples from four different farms, with 19 matching bioactive sequences. Bioactivities include dipeptidyl peptidase-IV (DPP-IV) inhibition, angiotensin-converting enzyme (ACE) inhibition, antioxidant activity, enhanced calcium uptake, and other peptides with potential antimicrobial effects. DPP-IV-inhibitory peptides (e.g., LDQWLCEKL and VGINYWLAHK) suggest potential for type 2 diabetes management, while ACE inhibitors (such as YLGY and FFVAPFPEVFGK) could s

SUBMITTER: De Fazio R 

PROVIDER: S-EPMC11898676 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature