Persistent delay in maturation of the developing gut microbiota in infants with cystic fibrosis.

ABSTRACT: The healthy human infant gut microbiome undergoes stereotypical changes in taxonomic composition between birth and maturation to an adult-like stable state. During this time, extensive communication between microbiota and the host immune system contributes to health status later in life. Although there are many reported associations between microbiota compositional alterations and disease in adults, less is known about how microbiome development is altered in pediatric diseases. One pediatric disease linked to altered gut microbiota composition is cystic fibrosis (CF), a multi-organ genetic disease involving impaired chloride secretion across epithelia and heightened inflammation both in the gut and at other body sites. Here, we use shotgun metagenomics to profile the strain-level composit

SUBMITTER: Verster AJ 

PROVIDER: S-EPMC11898760 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature