Characterizing the Natural History of Pediatric Brain Tumors Presenting with Metastasis.

ABSTRACT:

Background

The natural history of pediatric patients with metastasis of primary brain tumors within and outside the central nervous system is poorly understood, as too are possible clinical correlates with outcome. Correspondingly, the aim of this study was to interrogate a national database to characterize this diagnosis and its clinical course in pediatric patients.

Methods

The U.S. National Cancer Database (NCDB) was interrogated between the years 2005-2016 for all patients aged 18 years and younger with a primary brain tumor diagnosis, as well as evidence of disease metastasis at initial diagnosis. Data were summarized and overall survival (OS) was modeled using Kaplan-Meier and Cox regression analyses.

Results

Out of a total of 8615 pediatric brain tumor patients

SUBMITTER: Lu VM 

PROVIDER: S-EPMC11898785 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature