ARIH1 Inhibition Promotes Microtubule Stability and Sensitizes Breast Cancer Cells to Microtubule-Stabilizing Agents.

ABSTRACT: Background: Microtubule dynamics play a pivotal role in cancer progression and response to chemotherapeutics. Identifying regulators of microtubule stability can provide new therapeutic targets and predictive biomarkers for cancer treatment. Methods: We investigated the role of ARIH1, an E3 ubiquitin ligase, in breast cancer by analyzing clinical datasets to assess its expression levels and prognostic significance. Functional studies were conducted in breast cancer cell lines to evaluate the impact of ARIH1 depletion on microtubule stability, MAP4 regulation, and paclitaxel sensitivity. Results: Clinical dataset analysis revealed that ARIH1 expression is significantly elevated in breast cancer tissues and correlates with poor prognosis and reduced recurrence-free survi

SUBMITTER: Elshaer M 

PROVIDER: S-EPMC11898827 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature