A Pilot Study on Predicting Ocular Hypertension in Chinese Patients Undergoing Femtosecond Laser-Assisted Penetrating Keratoplasty.

ABSTRACT: Background: Ocular hypertension (OHT) can lead to corneal transplant failure, yet no predictive model exists for OHT after femtosecond laser-assisted penetrating keratoplasty (Fs-PKP). This study aimed to develop and validate a predictive nomogram for OHT in Chinese patients undergoing Fs-PKP. Methods: A retrospective cohort study at Nanjing First Hospital included 238 patients who underwent Fs-PKP and were followed up for two years. OHT was defined as postoperative intraocular pressure exceeding 21 mmHg or an increase of more than 10 mmHg from baseline. Twenty-three variables related to recipient, donor, and surgical factors were evaluated. Key predictors were identified using the least absolute shrinkage and selection operator (LASSO) method and multivariate Cox regression,

SUBMITTER: Cao X 

PROVIDER: S-EPMC11898841 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature