Molecular network analysis of CPEB4 translational control and targeting CPEB4/β-catenin to modulate invasion and migration of nasopharyngeal carcinoma cells.

ABSTRACT: Background: CPEB4, an RNA-binding protein that regulates the translational efficiency of target genes, has been implicated in playing dual roles in tumor progression across multiple cancer types. This study aims to investigate the role of CPEB4 in head and neck squamous cell carcinoma (HNSCC), particularly focusing on nasopharyngeal carcinoma. Methods: Differentially expressed proteins associated with CPEB4 were identified using iTRAQ-based proteomics. Consensus clustering stratified 495 HNSCC cases into two distinct molecular subtypes (C1 and C2). A prognostic risk model was constructed using LASSO regression. The effects of CPEB4 on cellular invasion and migration were analyzed in NPC cells. Western blotting assessed PI3K/AKT and WNT/β-catenin pathways and EMT markers. β-ca

SUBMITTER: Fen L 

PROVIDER: S-EPMC11898850 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature