<i>Lycorine hydrochloride</i> Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways.

ABSTRACT:

Background

Tumor metastasis and poor drug efficacy are two of the most common causes of therapeutic failure in cancer patients. The underlying molecular mechanism requires further exploration, and novel effective curative strategies are urgently needed. Nature is a rich source of novel drugs, and Lycorine hydrochloride (Lyc.HCL) is a natural alkaloid with tremendous therapeutic potential. However, the molecular mechanisms of its antitumor activity are still unknown. In the current study, we investigated the effects and mechanisms of Lyc.HCL against esophageal squamous cell carcinomas (ESCCs), which pose serious threats to human life.

Methods

An MTS assay and a clone formation assay were used to assess the viability of ESCC cell lines after Lyc.HCL

SUBMITTER: Liu J 

PROVIDER: S-EPMC11898953 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature