Structure Characterization and Treatment Effect of <i>Zingiber officinale</i> Polysaccharide on Dextran Sulfate Sodium-Induced Ulcerative Colitis.

ABSTRACT:

Background

Ulcerative colitis (UC) is on the rise all over the world. Zingiber officinale polysaccharide (ZOP-1) has good anti-inflammatory and antioxidant effects, but the therapeutic effect and mechanism of ZOP-1 on UC are still unclear.

Methods

ZOP-1 obtained by water extraction and alcohol precipitation was analyzed by methylation and NMR. At the same time, the mechanism of ZOP-1 in the treatment of UC was clarified by hematoxylin-eosin (HE) staining, metagenomics, immunohistochemistry, and protein blot (Wb).

Results

ZOP-1 was the structure of the by →4,6)-β-Glcp-1→ and →3,6)-α-Galp-(1→ constitute the main chain, there were two branched chain by →4)-β-Glcp(1→, and α-Araf(1→ as the end group. ZOP-1 significantly improved the shortening and thickening of the

SUBMITTER: Jing Y 

PROVIDER: S-EPMC11899033 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature