Proteogenomic Profiling of Treatment-Naive Metastatic Malignant Melanoma.

ABSTRACT:

Background

Melanoma is a highly heterogeneous disease, and a deeper molecular classification is essential for improving patient stratification and treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover molecular subtypes and clinically relevant biomarkers.

Methods

We performed an integrative proteogenomic analysis to identify proteomic subtypes, assess the impact of BRAF V600 mutations, and study the molecular profiles and cellular composition of the tumor microenvironment. Clinical and histopathological data were used to support findings related to tissue morphology, disease progression, and patient outcomes.

Results

Our analysis revealed five distinct proteomic subtypes

SUBMITTER: Kuras M 

PROVIDER: S-EPMC11899103 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature