Identification of Thyroid Genes Whose Expression Is Altered by Neonatal Irradiation in Rats.

ABSTRACT: Childhood radiation is a risk factor for thyroid cancer that became well known after the Chernobyl nuclear plant accident. Although these human cases have been extensively studied, the mechanisms underlying childhood susceptibility to radiation-induced thyroid cancer have yet to be explained. Our previous study showed that neonatal X-irradiation resulted in long-term alterations in the mRNA expression of thyroid cancer-related marker genes, which may be a critical mechanism for understanding the higher radiation sensitivity in young patients. In this study, RNA sequencing (RNA-Seq)-based gene expression analysis was employed to identify thyroid genes whose mRNA expression was changed by neonatal irradiation. Male Wistar rats aged 1 week and 4 months were subjected to cervical X-irradiation

SUBMITTER: Fujimoto N 

PROVIDER: S-EPMC11899105 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature