Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass.

ABSTRACT:

Background

Viral nervous necrosis (VNN) is an important viral disease threatening global aquaculture sustainability and affecting over 50 farmed and ecologically important fish species. A major QTL for resistance to VNN has been previously detected in European sea bass, but the underlying causal gene(s) and mutation(s) remain unknown. To identify the mechanisms and genetic factors underpinning resistance to VNN in European sea bass, we employed integrative analyses of multiple functional genomics assays in European sea bass.

Results

The estimated heritability of VNN resistance was high (h² ~ 0.40), and a major QTL explaining up to 38% of the genetic variance of the trait was confirmed on chromosome 3, with individuals with the resistant QTL genotype showing a 90%

SUBMITTER: Mukiibi R 

PROVIDER: S-EPMC11899128 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature