In Vitro-In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In-depth Case Study with Pyrene.

ABSTRACT: Computational models that predict chemical bioaccumulation in fish generally account for biotransformation using an apparent first-order whole-body rate constant (k_B ; d^-1 ). The use of such models requires, therefore, that methods exist for estimating k_B , ideally without the need to expose live animals. One promising approach for estimating k_B involves the extrapolation of measured in vitro intrinsic clearance (CL_{IN VITRO,INT} ) to the whole animal (in vitro-in vivo extrapolation, [IVIVE]). To date, however, the accuracy of such predictions has been difficult to assess due to uncertainties associated with one or more extrapolation factors and/or a mismatch between fish used to generate in vitro data and those used to conduct in vivo e

SUBMITTER: Nichols JW 

PROVIDER: S-EPMC11899409 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature