NIR-II Fluorescent Thermophoretic Nanomotors for Superficial Tumor Photothermal Therapy.

ABSTRACT: Peritumoral subcutaneous injection has been highly envisioned as an efficient yet low-risk administration of photothermal agents for superficial tumor photothermal therapy. However, obstructed by complex subcutaneous tissue, the delivery of injected photothermal agents to the specific tumor remains a critical issue. Herein, the study reports a polydopamine (PDA)-encapsulated spherical core/shell nanomotor with fluorescent indocyanine green (ICG) immobilized on its PDA shell. Upon the first near-infrared (NIR-I) irradiation, this motor can generate favorable photothermal heat, and meantime, emit a robust ICG fluorescence in the second near-infrared window (NIR-II). The heat turns the motor into an active photothermal agent able to perform thermophoretic propulsion along the irradiation dire

SUBMITTER: Jiang J 

PROVIDER: S-EPMC11899490 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature