Xolography for Biomedical Applications: Dual-Color Light-Sheet Printing of Hydrogels With Local Control Over Shape and Stiffness.

ABSTRACT: Current challenges in tissue engineering include creation of extracellular environments that support and interact with cells using biochemical, mechanical, and structural cues. Spatial control over these cues is currently limited due to a lack of suitable fabrication techniques. This study introduces Xolography, an emerging dual-color light-sheet volumetric printing technology, to achieve control over structural and mechanical features for hydrogel-based photoresins at micro- to macroscale while printing within minutes. A water-soluble photoswitch photoinitiator system and a library of naturally-derived, synthetic, and thermoresponsive hydrogels for Xolography are proposed. Centimeter-scale, 3D constructs with positive features of 20 µm and negative features of ≈100 µm are fabricated with

SUBMITTER: Stoecker L 

PROVIDER: S-EPMC11899501 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature