Optimizing sample size for supervised machine learning with bulk transcriptomic sequencing: a learning curve approach.

ABSTRACT: Accurate sample classification using transcriptomics data is crucial for advancing personalized medicine. Achieving this goal necessitates determining a suitable sample size that ensures adequate classification accuracy without undue resource allocation. Current sample size calculation methods rely on assumptions and algorithms that may not align with supervised machine learning techniques for sample classification. Addressing this critical methodological gap, we present a novel computational approach that establishes the accuracy-versus-sample size relationship by employing a data augmentation strategy followed by fitting a learning curve. We comprehensively evaluated its performance for microRNA and RNA sequencing data, considering diverse data characteristics and algorithm configuration

SUBMITTER: Qi Y 

PROVIDER: S-EPMC11899567 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature