Genomic Landscapes of Early-Onset Versus Average-Onset Colorectal Cancer Populations.

ABSTRACT:

Background

Rates of early-onset colorectal cancer (eoCRC), defined as disease diagnosed at <50 years of age, are increasing. The incidence and spectrum of somatic and pathogenic germline variants (PGV) in this population are not well understood.

Methods

This cross-sectional study leveraged Tempus' clinicogenomic database, including de-identified records of patients diagnosed with CRC between 2000-2022, to analyze and compare eoCRC and average-onset colorectal cancer (aoCRC, disease diagnosed ≥50 years of age) patients. The frequency and spectrum of somatic mutations and PGVs in patients with eoCRC and aoCRC were evaluated and compared.

Results

Among 11,006 participants in this study, 57% were male, 76% were white, and 80% had stage 4 disease. Within the total cohort,

SUBMITTER: Storandt MH 

PROVIDER: S-EPMC11899610 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature