Prognostic Significance of Sarcopenia in Patients Undergoing Surgery for Perihilar Cholangiocarcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

The aim of this study was to determine the impact of sarcopenia on outcomes in patients undergoing curative resection for perihilar cholangiocarcinoma.

Methods

A systematic review and meta-analysis following PRISMA standards were conducted, searching for studies comparing patients with and without sarcopenia undergoing surgery for perihilar cholangiocarcinoma. The outcomes included postoperative mortality, Clavien-Dindo ≥ 3 complications, intraoperative blood loss, need for blood transfusion, length of hospital stay, and overall survival (OS) (time-to-event). The odds ratio (OR), mean difference (MD), and adjusted hazard ratio (HR) were calculated as summary measures using random effect modelling. Risk of bias was assessed with the Quality in Prognosis Studies tool.

R

SUBMITTER: Efstathiou A 

PROVIDER: S-EPMC11899633 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature