Dietary and circulating omega-6 fatty acids and their impact on cardiovascular disease, cancer risk, and mortality: a global meta-analysis of 150 cohorts and meta-regression.

ABSTRACT:

Background

Despite the significant increase in omega-6 fatty acid consumption, evidence regarding their health impacts remains inconsistent. This study performs an umbrella review and updated meta-analysis to evaluate the association between dietary and circulating omega-6 levels and the risks of cardiovascular diseases (CVDs), cancer, and mortality.

Methods

A systematic search was conducted in PubMed, Scopus, and Web of Science until January 2024 to identify eligible meta-analyses of prospective observational studies. The Cochrane risk of bias and GRADE tools were used to assess the risk of bias and certainty of the evidence, respectively.

Results

Analysis of 150 publications revealed that higher dietary intake and circulating levels of omega-6 were associated with l

SUBMITTER: Sadeghi R 

PROVIDER: S-EPMC11899657 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature