Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian randomization study.

ABSTRACT:

Background

Epidemiological investigations provide considerable evidence supporting the coexistence of upper airway ailments with lower airway disorders, but the association between common nasal diseases, such as allergic rhinitis, chronic sinusitis, nasal polyps, and chronic respiratory conditions require further exploration.

Methods

In this study, a two-sample mendelian randomization was employed to explore the potential association between allergic rhinitis, nasal polyps, and chronic sinusitis with various chronic respiratory diseases. For the primary analysis, summary statistics related to chronic respiratory diseases were obtained from the UK Biobank of European ancestry. To externally validate the results, summary statistics related to chronic respiratory diseases were

SUBMITTER: Ren F 

PROVIDER: S-EPMC11899691 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature