The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes.

ABSTRACT:

Introduction

Impaired cerebrovascular reactivity (CVR) is common in type 2 diabetes (T2D) patients and is a risk factor for dementia. However, most prior functional magnetic resonance imaging (fMRI) studies in T2D disregarded the impact of impaired CVR on brain activation patterns. This study investigated the relationship between CVR and brain activation during an fMRI task in T2D patients.

Methods

Seventy-four T2D patients underwent a working-memory (WM) fMRI task. CVR was measured by the breath-holding index test using transcranial Doppler (TCD). Regression analyses examined associations between CVR and brain activation and between glycated hemoglobin (HbA1c) and activation with/without adjusting for CVR.

Results

An association between CVR and brain activation was f

SUBMITTER: Oliel Y 

PROVIDER: S-EPMC11899760 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature