Influence of Atherosclerosis-Associated Risk Factors on Expression of Endothelin Receptors in Advanced Atherosclerosis.

ABSTRACT: Endothelin-1 (ET-1) levels are altered in atherosclerosis, while the roles of the endothelin receptors ET_AR and ET_BR during the pathogenesis of atherosclerosis remain unclear. Therefore, the focus of this study was to clarify how endothelin receptors are expressed in advanced human atherosclerotic plaques and how this is related to atherosclerotic risk factors. Ex vivo expression analysis was performed by quantitative real-time PCR (qRT-PCR) of 98 atherosclerotic plaques and controls that were obtained from adult patients undergoing vascular surgery. Correlation analyses of atherosclerosis-promoting factors were accomplished using a linear regression model. We found an overall reduced expression of ET receptors and smooth muscle actin (SMA), a marker of healthy vascul

SUBMITTER: Herbers O 

PROVIDER: S-EPMC11899768 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature