Impact of Saharan Dust and <i>SERPINA1</i> Gene Variants on Bacterial/Fungal Balance in Asthma Patients.

ABSTRACT: The Canary Islands, a region with high asthma prevalence, are frequently exposed to Saharan Dust Intrusions (SDIs), as are a wide range of countries in Europe. Alpha-1 antitrypsin (SERPINA1 gene) regulates the airway's inflammatory response. This study analyzed the combined effect of SDI exposure and SERPINA1 variants on bacterial/fungal DNA concentrations in saliva and pharyngeal samples from asthmatic patients. Bacterial and fungal DNAs were quantified by qPCR in 211 asthmatic patients (GEMAS study), grouped based on their exposure to daily PM₁₀ concentrations. Associations between SDI exposure, microbial DNA concentrations, and nine variants in SERPINA1 were tested using linear regression models adjusted for confounders. The ratio between bacterial and fu

SUBMITTER: Escuela-Escobar A 

PROVIDER: S-EPMC11899813 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature