Densitometric and Functional Progression in Patients with Alpha-1 Antitrypsin Deficiency Genotype SZ.

ABSTRACT: Smoking is a key determinant of chronic obstructive pulmonary disease (COPD) development in patients with the SZ genotype. Few studies have evaluated the impact of other factors associated with emphysema progression. Objectives: To evaluate the progression of lung function and densitometric parameters in PiSZ alpha-1 antitrypsin deficiency (AATD) patients, and to assess the impact of smoking, exacerbation frequency, severity and time since diagnosis. The study also explores correlations between functional and densitometric measures, as well as regional emphysema patterns. Methods: This two-year observational study included 31 PiSZ AATD patients stratified by time since diagnosis (<5 vs. ≥5 years), smoking status (current, former, and never smokers), and exacerbation frequency

SUBMITTER: Esmaili S 

PROVIDER: S-EPMC11900030 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature