Transcriptional Profiling of Abomasal Mucosa from Young Calves Experimentally Infected with <i>Ostertagia ostertagi</i>.

ABSTRACT: Ostertagia ostertagi, also known as the brown stomach worm, causes significant pathology in the abomasum, resulting in production and nutritional losses in cattle. Alternative control measures, such as vaccination, are urgently needed because of rapidly growing anthelmintic drug resistance. There is a need to understand host responses to the infection, especially immune responses, to advance vaccine discovery and design. Therefore, the present study investigated comprehensive changes in gene transcription in the abomasal mucosa of cattle infected with O. ostertagi at 0, 3-5, 7-9, 10, and 21 days post-infection (dpi) using RNA sequencing (RNA-seq). Compared to uninfected controls, infected animals exhibited significant increases in differentially expressed genes (DEGs) through

SUBMITTER: Boschiero C 

PROVIDER: S-EPMC11900041 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature