Dys-regulated phosphatidylserine externalization as a cell intrinsic immune escape mechanism in cancer.

ABSTRACT: The negatively charged aminophospholipid, phosphatidylserine (PS), is typically restricted to the inner leaflet of the plasma membrane under normal, healthy physiological conditions. PS is irreversibly externalized during apoptosis, where it serves as a signal for elimination by efferocytosis. PS is also reversibly and transiently externalized during cell activation such as platelet and immune cell activation. These events associated with physiological PS externalization are tightly controlled by the regulated activation of flippases and scramblases. Indeed, improper regulation of PS externalization results in thrombotic diseases such as Scott Syndrome, a defect in coagulation and thrombin production, and in the case of efferocytosis, can result in autoimmunity such as systemic lupus eryth

SUBMITTER: Pulica R 

PROVIDER: S-EPMC11900106 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature