A Leg Cuticle Protein Enhances the Resistance of <i>Anopheles sinensis</i> Mosquitoes to Deltamethrin.

ABSTRACT: Insecticide resistance in mosquitoes has become a severe impediment to global vector control and manifests as decreased insecticide effectiveness. The role of target site mutations and detoxification enzymes as resistance markers has been documented in mosquitoes; however, the emergence of complex resistant phenotypes suggest the occurrence of additional mechanisms. Cuticular proteins (CPs) are key constituents of the insect cuticle, and play critical roles in insect development and insecticide resistance. In this study, via electron microscopy we observed that the leg cuticle thickness in deltamethrin-resistant (DR) Anopheles sinensis mosquitoes was significantly greater than that measured in deltamethrin-susceptible (DS) An. sinensis. Transcription analysis revealed that cu

SUBMITTER: Li L 

PROVIDER: S-EPMC11900137 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature