Dynamical effects of mechano-chemo-transduction on cardiac alternans.

ABSTRACT: In every heartbeat, cardiac muscle cells perform excitation-Ca²⁺ signaling-contraction (EC) coupling to pump blood against the vascular resistance. Cardiomyocytes can sense the mechanical load and activate mechano-chemo-transduction (MCT) mechanism, which provides feedback regulation of EC coupling. MCT feedback is important for the heart to upregulate contraction in response to increased load to maintain cardiac output. MCT feedback enhances the L-type Ca²⁺ current, sensitizes ryanodine receptors (RyRs), and augments SERCA pump activity, thereby maintaining contraction amplitude despite increased load. However, under certain conditions, MCT feedback can also promote cardiac alternans, seen as beat-to-beat variations in action potential duration, Ca²⁺ trans

SUBMITTER: Sato D 

PROVIDER: S-EPMC11900190 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature