Understanding the coarse-grained free energy landscape of phospholipids and their phase separation.

ABSTRACT: The cell membrane exhibits lateral heterogeneity due to the preferential association among the large number of lipid species that constitute the membrane. In particular, the preferential association of cholesterol (CHOL) with saturated lipids into ordered domains has been an area of intense investigation. The large spatiotemporal scales that comprise spontaneous domain formation largely precludes computational investigation via conventional all-atom molecular dynamics. We demonstrate here that molecular coarse-grained (CG) models, obtained from the bottom-up, i.e., via statistical mechanical renormalization of atomistic models, are capable of spontaneous assembly and phase separation for two model raft-like systems, DLiPC/DPPC/CHOL and DOPC/DPPC/CHOL. The resulting bottom-up CG models exhi

SUBMITTER: Sahrmann PG 

PROVIDER: S-EPMC11900191 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature