Enhancing understanding of endometrial function in patients with PCOS: clinical and immunological insights.

ABSTRACT:

Objective

To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium of PCOS patients and explore its relationship with various PCOS phenotypes.

Design

Retrospective cohort study.

Setting

A single academically affiliated reproductive medicine center.

Patients

21,074 FET cycles were included and divided into two groups based on the diagnosis of PCOS. Patients with PCOS were further categorized into four phenotypic groups: PCOM + HA + OA, PCOM + HA, PCOM + OA, and HA + OA. Endometrial biopsies from 21 PCOS patients and 26 controls were obtained to analyze T cell subsets.

Methods

Pregnancy

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11900192 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature