Cellular senescence predicts breast cancer risk from benign breast disease biopsy images.

ABSTRACT:

Background

Each year, millions of women undergo breast biopsies. Of these, 80% are negative for malignancy but some may be at elevated risk of invasive breast cancer (IBC) due to the presence of benign breast disease (BBD). Cellular senescence plays a complex but poorly understood role in breast cancer development and the presence or absence of these cells may have prognostic value.

Methods

We conducted a case-control study, nested within a cohort of 15,395 women biopsied for BBD at Kaiser Permanente Northwest between 1971 and 2006. Cases (n = 512) were women who developed a subsequent invasive breast cancer (IBC) at least one year after the BBD biopsy; controls (n = 491) did not develop IBC during the same follow-up period. Using H&E-stained biopsy images, we predicted sene

SUBMITTER: Heckenbach I 

PROVIDER: S-EPMC11900263 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature