Comparatively profiling the transcriptome of human, Porcine and mouse oocytes undergoing meiotic maturation.

ABSTRACT:

Background

Oocyte maturation is a critical process responsible for supporting preimplantation embryo development and full development to term. Understanding oocyte gene expression is relevant given the unique molecular mechanism present in this gamete. Comparative transcriptome analysis across species offers a powerful approach to uncover conserved and species-specific genes involved in the molecular regulation of oocyte maturation throughout evolution.

Results

Transcriptome analysis identified 4,625, 3,824, 4,972 differentially expressed genes (DEGs) between the germinal vesicle (GV) and metaphase II (MII) stage in human, porcine and mouse oocytes respectively. These DEGs showed dynamic changes associated with oocyte maturation. Functional enrichment analysis revealed that

SUBMITTER: Zhou N 

PROVIDER: S-EPMC11900275 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature