Optimization of Surfactant-Mediated Green Extraction of Phenolic Compounds from Grape Pomace Using Response Surface Methodology.

ABSTRACT: Grape pomace is a by-product abundant in phenolic compounds that can be used in the food, cosmetic, and pharmaceutical industries. For the efficient extraction of such compounds, an aqueous solution of non-ionic surfactant Brij S20 was applied as a green extraction medium, and the optimization was performed using surface response methodology. The effects of four independent factors (surfactant concentration, time, pH, and solvent-to-material ratio) were evaluated, and total phenolic content (TPC), DPPH radical inhibition, and selected polyphenol compound concentrations were analyzed as responses. Using response surface methodology (RSM), five regression equations were derived and good adequacy of the models was confirmed. The solvent-to-material (SM) ratio was the most influential factor.

SUBMITTER: Atanackovic Krstonosic M 

PROVIDER: S-EPMC11900315 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature