Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naive schizophrenia.

ABSTRACT:

Background

The elevated prolactin levels in first-episode drug-naïve (FEDN) schizophrenia patients may correlate with long-term stress caused by childhood trauma. This study aimed to assess the relationship between elevated prolactin levels and childhood trauma in FEDN schizophrenia patients, while also considering sex differences.

Methods

Utilizing a cross-sectional design, the study involved 88 FEDN schizophrenia patients and 76 healthy controls (HCs). Evaluations encompassed measuring prolactin levels in peripheral blood and assessing mental health using the Positive and Negative Syndrome Scale (PANSS), the Childhood Trauma Questionnaire - Short Form (CTQ-SF), as well as evaluating resilience with the Connor-Davidson Resilience Scale (CD-RISC), perceived social support wi

SUBMITTER: Pan Y 

PROVIDER: S-EPMC11900333 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature