Evaluation of Aciclovir-Induced Nephrotoxicity in Critically Ill Patients: A Propensity-Matched Cohort Study.

ABSTRACT: Background/Objectives: Aciclovir is a widely used antiviral agent. Since aciclovir is primarily eliminated through the kidneys, maintaining renal function is crucial to avoid toxicity. Although mitigating strategies are introduced in the standard of care, nephrotoxicity is still a major concern during treatment, especially for critically ill intensive care unit (ICU) patients. Therefore, risk factors for the development of nephrotoxicity during aciclovir therapy should be addressed. This study aimed to evaluate if aciclovir in combination with therapeutic drug monitoring (TDM) and additional nephrotoxicity-mitigating strategies is associated with a decrease in renal function in critically ill ICU patients. Methods: In a cohort of ICU patients with or without intravenous acicl

SUBMITTER: Boosman RJ 

PROVIDER: S-EPMC11900339 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature