A Systems Biology Approach for Prioritizing ASD Genes in Large or Noisy Datasets.

ABSTRACT: Autism spectrum disorder (ASD) is a complex multifactorial neurodevelopmental disorder. Despite extensive research involving genome-wide association studies, copy number variant (CNV) testing, and genome sequencing, the comprehensive genetic landscape remains incomplete. In this context, we developed a systems biology approach to prioritize genes associated with ASD and uncover potential new candidates. A Protein-Protein Interaction (PPI) network was generated from genes associated to ASD in a public database. Leveraging gene topological properties, particularly betweenness centrality, we prioritized genes and unveiled potential novel candidates (e.g., CDC5L, RYBP, and MEOX2). To test this approach, a list of genes within CNVs of unknown significance, identified throug

SUBMITTER: Remori V 

PROVIDER: S-EPMC11900372 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature