Hydrophilic Sulfonate Covalent Organic Frameworks for Serum Glycopeptide Profiling.

ABSTRACT: Aberrant protein glycosylation is closely associated with a number of biological processes and diseases. However, characterizing the types of post-translational modifications (PTMs) from the complex biological samples is challenging for comprehensive glycoproteomic analysis. The development of high-performance enrichment materials and strategies during the sample pretreatment process is a prerequisite to glycoproteome research. Here in this work, a sulfonate-rich covalent organic framework (COF) called TpPa-(SO₃H)₂ (referred to as SCOF-2) was synthesized using the Schiff base reaction for the identification of glycopeptides. Benefiting from high hydrophilicity and abundant sulfonate affinity, a total of 28 and 16 glycopeptides could be efficiently detected from the st

SUBMITTER: Yang S 

PROVIDER: S-EPMC11900406 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature