Viral Network Analyzer (VirNA): A Novel Minimum Spanning Networks Algorithm for Investigating Viral Evolution.

ABSTRACT: Next Generation Sequencing technologies are essential in public health surveillance for tracking pathogen evolution, spread, and the emergence of new variants. However, the extensive sequencing of viral genomes during recent pandemics has highlighted the limitations of traditional molecular phylogenetic algorithms in capturing fine-grained evolutionary details when analyzed sequences are highly similar and datasets are large-scale. VirNA (Viral Network Analyzer) addresses this challenge by reconstructing detailed mutation patterns and tracing pathogen evolutionary routes in specific geographical regions through Minimum Spanning Networks. It enables users to analyze thousands of sequences, generating networks where nodes represent genomic sequences linked to their metadata, while edges repr

SUBMITTER: Mazzotti G 

PROVIDER: S-EPMC11900457 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature