The Role of Primary Cilia in Modulating the Luteinization Process of Ovarian Granulosa Cells in Mice.

ABSTRACT: The corpus luteum is the principal progesterone-secreting gland, while primary cilia function as pivotal organelles in intercellular signal transduction. Together, they play an essential role in the establishment and maintenance of pregnancy. However, the mechanisms underlying the role of primary cilia in granulosa cell luteinization in mouse ovaries remain poorly understood. This study discovered the regularity of primary cilia in mouse ovaries and revealed the role of primary cilia in regulating progesterone synthesis in luteinized granulosa cells. In vivo test results showed that the expression of primary cilia was obvious in the corpus luteum. The secretion of P4 in mice was significantly increased at 6, 12, 24, 48, and 72 h. The secretion of P4 and the expressions of luteinization mar

SUBMITTER: Long X 

PROVIDER: S-EPMC11900466 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature