Comprehensive Analysis of Strong Opioid Side Effects in Palliative Care Using the SIDER Database.

ABSTRACT: Background/Objectives: There exist multiple opioid-based treatments in palliative care, each with distinct side effect profiles. When adverse events occur, switching opioids can help maintain effective pain management. However, owing to limited clinical evidence, no comprehensive guidelines exist for opioid switching. This study employed the Side Effect Resource (SIDER) database, which aggregates adverse event data from clinical trials and package inserts, to analyze the side effects of five commonly used "strong opioids" in palliative care in Japan, namely morphine, fentanyl, oxycodone, hydromorphone, and tapentadol. Methods: Data on the names and incidence of adverse events for each opioid were extracted from SIDER 4.1, developed by the Max Delbrück Center for Molecular Med

SUBMITTER: Hirai R 

PROVIDER: S-EPMC11900551 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature