<i>MUC5B</i> Polymorphism in Patients with Idiopathic Pulmonary Fibrosis-Does It Really Matter?

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a rare disorder concerning elderly people, predominantly men, active or former smokers, with a progressive nature and leading to premature mortality. The cause of the disease is unknown. However, there are some risk factors, among which genetic predisposition plays a role. The aim of our single-centered observational study was to assess the correlation between single nucleotide polymorphism (SNP) of the MUC5B gene (rs35705950) and the disease course, antifibrotic treatment effect, and survival in patients with IPF. A total of 93 patients entered the study, of whom 88 were treated with either nintedanib or pirfenidone. The GG genotype was found in 28 (30.1%) subjects, while the GT or TT genotypes were found in the remaining 65 (63.4%) and 6 (6.5

SUBMITTER: Lewandowska KB 

PROVIDER: S-EPMC11900561 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature