Development and validation of a population pharmacokinetic model of vancomycin for patients of advanced age.

ABSTRACT:

Background

Population pharmacokinetic (PPK) models of vancomycin (VCM) commonly use creatinine clearance (CLcr) as a covariate for clearance (CL). However, relying on CLcr in patients of advanced age may lead to inaccuracies in estimating VCM clearance. Therefore, this study aimed to develop and validate a new PPK model specifically for patients aged 75 years and older.

Methods

PPK analysis was performed based on the blood concentrations of VCM (n = 159 patients). The predictive performance of the developed model was compared with that of previous models using mean absolute error (MAE) and mean squared error (MSE) for another dataset.

Results

The PPK analysis optimized a two-compartment model using CLcr and the Alb levels as covariates at the central compartment of VC

SUBMITTER: Takada K 

PROVIDER: S-EPMC11900651 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature