Identification of two biological subgroups of complex regional pain syndrome type 1 by transcriptomic profiling of skin and blood in women.

ABSTRACT:

Background

Patients with Complex Regional Pain Syndrome (CRPS) present prolonged, debilitating pain and functional impairment. Treatments are not disease-modifying due to the poorly understood underlying pathomechanisms. This study aimed to identify the molecular signatures of potential CRPS type 1 subgroups.

Methods

Twelve women with CRPS type 1 were included. Demographics and pain questionnaires were recorded. Skin biopsies of the affected and non-affected limbs (n = 6 + 6) and peripheral blood (n = 11) were collected. RNA sequencing was performed on skin and peripheral blood mononuclear cells (PBMCs). Twenty cytokines were quantified in blood plasma (n = 12).

Results

Cluster analysis of the affected skin identified two CRPS subgroups (SG). SG1 exhibited increased g

SUBMITTER: Perez Vertti Valdes M 

PROVIDER: S-EPMC11900654 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature