Bitter Taste Receptors 38 and 46 Regulate Intestinal Peristalsis.

ABSTRACT: Bitter taste receptors (TAS2Rs) are expressed in extraoral tissues, exerting several functions and generating a whole-body chemosensory and protective system. TAS2Rs expression has been observed in the gastrointestinal tract, although their role is poorly understood. This study aims to investigate the role of TAS2R38 and 46 in human intestinal smooth muscle cells (HISMCs) after activation with the specific bitter ligands phenylthiocarbamide and absinthin, respectively. We found that TAS2R38 and 46 activation by phenylthiocarbamide (PTC) and absinthin, respectively, induces a rapid membrane depolarization and increase of cytosolic calcium levels due to internal storage in the IP₃ pathway, resulting in an accelerated cell contraction. Overall, this study unravels, for the first ti

SUBMITTER: Camillo L 

PROVIDER: S-EPMC11900946 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature