Putative Epigenetic Regulator microRNAs (epi-miRNAs) and Their Predicted Targets in High-Fat Diet-Induced Cardiac Dysfunction: An In Silico Analysis in Obese Rats.

ABSTRACT: Obesity-related cardiac dysfunction is a significant global health challenge. High-fat diets (HFDs) are well-established models of obesity. HFD has been reported to induce cardiac dysfunction and alter cardiac miRNA expression, DNA methylation and histone modifications. Nevertheless, it remains unclear whether cardiac miRNAs altered due to HFD target epigenetic regulator enzymes and function as epigenetic regulator miRNAs (epi-miRNAs), thereby contributing to HFD-induced epigenetic changes and cardiac dysfunction. To address this gap in our knowledge, this study aimed to identify putative cardiac epi-miRNAs and their potential epigenetic targets through an in silico analysis of a previously published miRNA dataset from Sprague Dawley rats subjected to HFD. Using two independent databases,

SUBMITTER: Pipicz M 

PROVIDER: S-EPMC11900980 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature