The Therapeutic Potential of Gut-Microbiota-Derived Metabolite 4-Phenylbutyric Acid in <i>Escherichia coli</i>-Induced Colitis.

ABSTRACT: Pathogenic Escherichia coli (E. coli) is a widely distributed pathogen that can cause varying degrees of zoonotic diseases, and infected animals often experience intestinal inflammation accompanied by diarrhea and dysbiosis. Previously, for the first time, we isolated Escherichia coli primarily of type B2 from a large-scale dairy farm in Yunnan, China. The 16s rRNA sequencing showed significant differences in the gut microbiota of calves infected with B2 E. coli, with higher abundance of harmful bacteria and lower abundance of beneficial bacteria compared with healthy calves. The metabolomics indicated that the concentrations of oxoadipic acid, 16-oxopalmitate, oerillyl alcohol, palmitoleic acid, and 4-phenylbutyrate (4-PBA) were significantly higher in the heal

SUBMITTER: Wang K 

PROVIDER: S-EPMC11901052 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature