Construction of Antibacterial MoS₂-ACF Phenotype Switcher for Bidirectionally Regulating Inflammation-Proliferation Transition in Wound Healing.

ABSTRACT: The transition between the inflammatory phase and the proliferative phase is critical for wound healing. However, the development of proper switchers that can regulate this transition is facing great challenges. Macrophages play versatile roles in all wound healing phases because they can readily switch from pro-inflammatory M1 phenotypes to anti-inflammatory M2 phenotypes in response to different microenvironment stimuli. Herein, taking advantage of enhanced electron transfer by coupling MoS₂ with a highly conductive activated carbon fiber (ACF) network, a MoS₂-ACF heterojunction structure was constructed as a macrophage M1-M2 phenotype switcher (MAPS) for regulating inflammation-proliferation transition to accelerate wound healing. In the early stages of wound repai

SUBMITTER: Mao M 

PROVIDER: S-EPMC11901119 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature