Impact of Tick-Borne <i>Orthoflaviviruses</i> Infection on Compact Human Brain Endothelial Barrier.

ABSTRACT: Tick-borne encephalitis remains a significant burden on human health in the endemic areas in Central Europe and Eastern Asia. The causative agent, tick-borne encephalitis virus (TBEV), is a neurotropic virus belonging to the genus of Orthoflavivirus. After TBEV enters the central nervous system (CNS), it mainly targets neurons, causing encephalitis and leading to life-long disabilities, coma and, in rare cases, death. The neuroinvasive mechanisms of orthoflaviviruses are poorly understood. Here we investigate the mechanism of TBEV neuroinvasion, hypothesizing that TBEV influences blood-brain barrier (BBB) properties and uses transcellular routes to cross the endothelial barrier and enter the CNS. To test this hypothesis, we employed an in vitro transwell system consisting of endothe

SUBMITTER: Schweitzer F 

PROVIDER: S-EPMC11901142 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature