Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release.

ABSTRACT: The increase in life expectancy has led to a rise of musculoskeletal disorders. Calcium phosphate cements (CPCs), thanks to some amazing features such as the ability to harden in vivo, bioactivity, and resorbability, are promising candidates to treat these diseases, notwithstanding their poor mechanical properties. We aimed to synthesise pure and barium- or silicon-doped brushite-based CPCs loaded with piroxicam to study the effects of the substitution on physical-chemical and pharmaceutical properties before and after cement immersion in phosphate buffer for different time periods. Our results demonstrated that piroxicam became amorphous in the hardened cements. The dopants did not change the brushite structure or its lamellar morphology, while both Ba and Si additions improved the initia

SUBMITTER: Bini M 

PROVIDER: S-EPMC11901259 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature